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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Geraniol, Fluorouracil
Phytochemical Name Geraniol (PubChem CID: 637566 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 939
Pair Name Geraniol, Fluorouracil
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression MTOR hsa2475
Up-regulation Expression PTEN hsa5728
Down-regulation Expression TYMS hsa7298
In Vivo Model The aim of the current work is to investigate the potential therapeutic as well as chemosensitizing effects of geraniol on breast carcinoma induced in mice through examination of tumour biomarkers and histopathology profile.
Result It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs.
Combination Pair ID: 940
Pair Name Geraniol, Fluorouracil
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->DNA synthesis
In Vitro Model Caco-2 Colon adenocarcinoma Homo sapiens (Human) CVCL_0025
SW620 Colon adenocarcinoma Homo sapiens (Human) CVCL_0547
In Vivo Model Colorectal tumor TC118 obtained from patients was grafted by subcutaneous implantation of 15 mm3 tumor fragments into the scapular area of nude mice.
Result Geraniol modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts
03. Reference
No. Title Href
1 Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling. J Pharm Pharmacol. 2023 Aug 1;75(8):1130-1139. doi: 10.1093/jpp/rgad060. Click
2 Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 2004 Nov 8;215(1):53-9. doi: 10.1016/j.canlet.2004.06.019. Click
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