Pair Name | Geraniol, Fluorouracil | ||
Phytochemical Name | Geraniol (PubChem CID: 637566 ) | ||
Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Geraniol, Fluorouracil | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Gene Regulation | Down-regulation | Expression | MTOR | hsa2475 |
Up-regulation | Expression | PTEN | hsa5728 | |
Down-regulation | Expression | TYMS | hsa7298 | |
In Vivo Model | The aim of the current work is to investigate the potential therapeutic as well as chemosensitizing effects of geraniol on breast carcinoma induced in mice through examination of tumour biomarkers and histopathology profile. | |||
Result | It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs. |
Pair Name | Geraniol, Fluorouracil | |||
Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
Biological Phenomena | Induction-->DNA synthesis | |||
In Vitro Model | Caco-2 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0025 |
SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
In Vivo Model | Colorectal tumor TC118 obtained from patients was grafted by subcutaneous implantation of 15 mm3 tumor fragments into the scapular area of nude mice. | |||
Result | Geraniol modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts |
No. | Title | Href |
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1 | Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling. J Pharm Pharmacol. 2023 Aug 1;75(8):1130-1139. doi: 10.1093/jpp/rgad060. | Click |
2 | Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 2004 Nov 8;215(1):53-9. doi: 10.1016/j.canlet.2004.06.019. | Click |